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氚╇�戈祼靾�&苍产蝉辫;Steffen Vanneste 靹鸽�鸽倶 臧曥棸

2018雲� 5鞗� 14鞚�, 瓴愴姼雽� 氤戈祼 氚╇�戈祼靾� Steffen Vanneste電� 鞁濏拡 氙胳儩氍检棎 雽�頃� 頋ル�鸽�滌毚 臧曥棸鞚� 歆勴枆頄堧嫟. 鞓レ嫚鞚� 鞁濍�检棎靹� 氚滉铂霅橂姅 頋�攴�頃� 順鸽ゴ氇�鞙茧�滌崹 鞁濍�� 靹膘灔鞐� 鞓來枼鞚� 欤缄碃, 鞚� 順鸽ゴ氇�鞚� 鞛戩毄 鞏戩嫕鞚� 鞚错暣頃橁赴 鞙勴暣靹滊姅 鞓レ嫚鞚� 鞚措彊 氅旍护雼堨�橃潉 韺岇晠頃橂姅瓴冹澊 欷戩殧頃橂嫟. 靹疙彫 氚栰溂搿� 鞝勳啞霅� 鞓レ嫚鞚� 鞗愴槙歆� 毵夓棎 鞙勳箻頃� 靾橃啞觳措ゼ 鞎堨爼鞁滌紲 鞁濍�� 靹膘灔鞐� 鞓來枼鞚� 欷�雼�. 鞖半Μ電� 鞓レ嫚鞚� 鞙犽弰頃� 旃检姌 鞁犿樃臧� 鞚� 瓿检爼鞐� 鞐�頃犾潉 頃� 靾� 鞛堨潉瓯半澕瓿� 臧�鞝曧晿鞐� 鞓レ嫚 鞙犽弰 旃检姌 鞁犿樃毳� 雼る（旮� 鞙勴暣靹� 鞁犿樃臧� 靸濎劚頃橂姅 雿办棎 鞏奠牅頃橂姅 鞛戩潃 攵勳瀽霌れ棎 雽�頃� 頇旐暀-鞙犾爠鞝� 鞀ろ伂毽办潉 韱淀暣 臁办偓毳� 頄堦碃, 鞏奠牅鞝滊摛鞚� 韱淀暣靹� 旃检姌 鞁犿樃臧� 鞓レ嫚 靾橃啞觳挫潣 鞛愲彊臁办爤 鞐�頃欖棎 毵庫潃 鞓來枼鞚� 雭检箿雼る姅 瓴冹潉 氚滉铂頄堧嫟. 霕愴暅 旃检姌鞚� 臧愳��霅橂姅 瓿检爼鞐� 雽�頃橃棳 臁办偓毳� 頃橃榾電旊嵃 旃检姌鞐� 鞚橃〈頃橂姅 韨る倶鞎勳牅霌� 欷� 鞓レ嫚 靾橃啞觳措ゼ 鞎堨爼鞁滍偆電� 臧曧暅 須�靻岆摛鞚� 臁挫灛頃滊嫟電� 瓴冹潉 氚滉铂頃橃榾鞙茧┌ 鞚搓矁霌れ澊 鞓レ嫚 鞚措彊鞐� 鞓來枼鞚� 欤茧姅 鞛犾灛鞝侅澑 雽�響� 靹彪秳鞚挫棃雼�. 鞚� 瓴诫�滌棎 霐半ジ 雿� 毵庫潃 瓿检爼 氍橃偓毳� 韱淀暣靹� 鞁濍�� 靹膘灔鞚� 雮措秬 瓿检爼鞚� 鞚错暣頃� 靾� 鞛堨溂氅�, 雿� 雮橃晞臧� 鞛リ赴鞝侅溂搿� 雴嶌梾 韸轨劚鞚� 臧滌劆霅� 靾� 鞛堧姅 鞝勲灥鞚� 靹胳毎電� 雿办棎 霃勳泙霅� 瓴冹澊雼�.

Steffen Vanneste 甑愳垬電� 瓿淀暀氚曥偓頃欖渼毳� 氚涭晿瓿� 順勳灛 瓴愴姼雽�頃欔祼鞕� VIB 鞐瓣惮靻� 鞁濍�检嫓鞀ろ厹靸濍�柬暀頃欕秬鞐愳劀 鞐瓣惮鞗愳溂搿� 鞐瓣惮頇滊彊鞚� 歆勴枆欷戩澊雼�.

Scheme of auxin-induced Ca2+ signals and Interplay between auxin transport and calcium    

鞗愲��: Calcium- The Missing Link in Auxin Action

Auxin is an elusive plant hormone, affecting nearly every aspect of plant development. Key to understanding auxin's mode of action is unraveling the mechanisms of self-regulated auxin transport. In this model, auxin that is transported out of the cell stabilizes the auxin transporters at the plasma membrane, thus generating a self-organizing subcellular asymmetry in auxin transport capacity that drives plant development. However, the mechanism of how auxin regulates auxin transport asymmetry is not well understood. We postulated that auxin-induced calcium signaling could represent an important piece in the puzzle. to be able to manipulate auxin-induced calcium signaling, we performed a chemical genetic screen for small molecules that inhibit auxin-induced calcium signaling. Via these inhibitors, we found that calcium signaling severely impacts on the self-regulated dynamics of auxin transporters. Following up on this finding we zoomed in on the corresponding calcium-sensing machinery. Using a conditional induction system, we found that a subgroup of calcium-dependent kinases has a strong potency to stabilize auxin transporters at the plasma membrane, possibly representing a novel element in the pathway of self-regulated auxin transport. Further characterization of this pathway will lead to a better understanding of the inner workings of plant growth and development which, in the long term, will allow designing strategies to improve agricultural traits.

References:

http://www.mdpi.com/2223-7747/2/4/650